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  • 李志刚
    李志刚主任医师
    中西医结合科主任、教授、博士、博士后。...
预约价格:20元
医疗专长:
外科
科研方向:
肿瘤发生与转移机制研究
出诊时间
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个人简介:

具有三十余年普外科,胸外科和中西医结合肿瘤综合治疗临床工作经验。

曾在日本京都大学攻读博士和在美国安德森癌症中心从事博士后肿瘤细胞分子医学研究经历;2008年从美国回国后,分别在天津医科大学总医院和天津市中西医结合医院南开医院从事肿瘤基础研究和临床工作。期间积极推行以各种微创技术对肿瘤微创、有效“祛邪”和以中医药治疗对肿瘤患者“扶正”的整体、综合、个体化治疗理念。尤其是在中国工程院院士和国医大师吴咸中教授指导下,在国内率先开展以“五师查房”的方式开展中西医结合肿瘤综合治疗。目前主要开展氩氦刀冷冻,射频消融和放射性粒子植入等微创技术,对全身各部位良、恶性实体肿瘤,如头颈部肿瘤,胸部肿瘤,消化道肿瘤、泌尿系肿瘤,妇科肿瘤及骨肿瘤等进行清除或消融,同时对肿瘤患者给予中医药调理,营养治疗,规范化止痛和心理疏导等综合治疗。

学术职务:

中国抗癌协会第一届肿瘤热疗专业委员会委员

中国中西医结合学会营养学专业委员会委员

中国中西医结合学会第一届围手术期专业委员会委员

天津市中西医结合学会第五届理事会常务理事

天津市中西医结合学会第三届普外专业委员会副主任委员

天津市中西医结合学会第三届肿瘤专业委员会副主任委员

海南省抗癌学会肿瘤消融(介入)专业委员会 会员

中国中西医结合外科杂志编委 常务编委(肿瘤)

中国肺癌杂志 编委

美国癌学会会员

日本癌学会会员

中国旅美专家协会会员

中国医师协会会员

中华医学会会员

中国心胸外科协会会员

中国抗癌协会会员

中国中西医结合学会会员

论文著作:

1、Ze-Han Liu, Qi Zhang, Yi-Jie Ding, Ying-Hui Ren, Hui-Peng Yang, Qing Xi, Ying-Nan Cheng, Guo-Lin Miao, Hong-Kun Liu, Cai-Xia Li, Wen-Qiang Yan, Yan Li, Zhenyi Xue, Li-juan Zhang, Xin-Ye Li, Chen-Long Zhao, Yurong Da, Xian-Zhong Wu, Jun-Qiang Chen, Rongxin Zhang, Zhi-Gang Li(李志刚,通讯),Overexpression of CHD1L is Associated with Poor Survival and Aggressive Tumor Biology in Esophageal Carcinoma. Oncotarget. 2017 Jun 29. doi: 10.18632/oncotarget.18830 (IF: 5.168).  

2、Guo F, Jiao F, Song Z, Li S, Liu B, Yang H, Zhou Q, Li Z(李志刚,通讯 Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung cancer cells in vitro. Biochem Biophys Res Commun, 2015, Sept  465(2):293-298. (IF2.371Cited:3).

3、Guo F, Guo L, Li Y, Zhou Q, Li Z(李志刚,通讯MALAT1 is an oncogenic long non-coding RNA associated with tumor invasion in non-small cell lung cancer regulated by DNA methylation. Int J Clin Exp Pathol, 2015, Dec 8(12):15903-15910. (IF1.581Cited:2).

4、Yan S, Tian S, Kang Q, Xia Y, Li C, Chen Q, Zhang S, Li Z(李志刚,通讯)Rhizoma Paridis Saponins Suppresses Tumor Growth in a Rat Model of N-Nitrosomethylbenzylamine-Induced Esophageal Cancer by Inhibiting Cyclooxygenases-2 Pathway. PLoS One. 2015 Jul 6;10(7): IF3.75cited:0).

5、Wang DB1, Lu XK, Zhang X, Li ZG(李志刚), Li CX. Carbonic anhydrase 1 is a promising biomarker for early detection of non-small cell lung cancer. Tumour Biol. 2015 Aug 1. IF3.6 cited:2).

6、Li S, Li Z(李志刚,并列)Guo F, Qin X, Liu B, Lei Z, Song Z, Sun L, Zhang HT, You J, Zhou Q. miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma. J Biomed Sci. 2011 Mar 31;18:24IF2.4 cited:77).

7、Wan X, Li ZG(李志刚) Yingling JM, Yang J, Starbuck MW, Ravoori MK, Kundra V, Vazquez E, Navone NM. Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth. Bone. 2012 Mar;50(3):695-703. IF4.09, cited:29 ).

8、Mohamedali KA, Li ZG(李志刚), Starbuck MW, Wan X, Yang J, Kim S, Zhang W, Rosenblum MG, Navone NM.Inhibition of prostate cancer osteoblastic progression with VEGF121/rGel, a single agent targeting osteoblasts, osteoclasts, and tumor neovasculature. Clin Cancer Res. 2011 Apr 15;17(8):2328-38. Epub 2011 Feb 22.IF6.5 , cited:22).

9、Li ZG(李志刚), Mathew P, Yang J, Starbuck MW, Zurita AJ, Liu J, Sikes C, Multani AS, Efstathiou E, Lopez A, Wang J, Fanning TV, Prieto VG, Kundra V, Vazquez ES, Troncoso P, Raymond AK, Logothetis CJ, Lin SH, Maity S, Navone NM. Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest. 2008 Aug;118(8):2697-710.IF16.915 , cited:104).

10、Li ZG(李志刚), J Yang, ES Vazquez, D Rose, F Vakar-Lopez, P Mathew, A Lopez, CJ Logothetis, S-H Lin and NM Navone. Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene. 2008 Jan 24;27(5):596-60 (IF: 6.872 cited:53).

11、Li ZG(李志刚), Heidi Y Shi and Ming Zhang. Targeted expression of maspin in tumor vasculatures induces endothelial cell apoptosis. Oncogene. 2005 Mar 17;24(12):2008-19 (IF:6.872, cited:132).

12、Li ZG(李志刚), Hong T, Shimada Y, Komoto I, Kawabe A, Ding Y, Kaganoi J, Hashimoto Y, Imamura M. Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis. 2002 Sep;23(9):1531-6 (IF: 5.406 , cited:260 ).

13、Li ZG(李志刚), Shimada Y, Kawabe A, Sato F, Maeda M, Komoto I, Hong T, Ding Y, Kaganoi J, Imamura M. Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor. Carcinogenesis. 2001 Apr;22(4):547-51. (IF:5.406 , cited:238).

14、Li ZG(李志刚),  Schem C, Shi YH, Medina D, Zhang M. Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis. Clin Exp Metastasis.  2008; 25(4):389-400. (IF: 2.514, cited:114).

15、Li ZG(李志刚), Shimada Y, Uchida S, Maeda M, Kawabe A, Mori A, Itami A, Kano M, Watanabe G, Imamura M. TGF-alpha as well as VEGF, PD-ECGF and bFGF contribute to angiogenesis of esophageal squamous cell carcinoma. Int J Oncol. 2000 Sep;17(3):453-60. (IF:2.931, cited:92) .

16、Li ZG(李志刚), Shimada Y, Sato F, Maeda M, Itami A, Kaganoi J, Komoto I, Kawabe A, Imamura M. Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats. Int J Oncol. 2002 Dec; 21(6):1275-83 (IF: 2.931, cited:79).

17、Li ZG(李志刚), Shimada Y, Sato F, Maeda M, Itami A, Kaganoi J, Komoto I, Kawabe A, Imamura M. Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats. Oncol Rep. 2003 Mar-Apr;10(2):421-6 (IF: 1.597, cited:88).

18、Nagatani S, Shimada Y, Li ZG(李志刚), Kaganoi J, Kan T, Maeda M, Watanabe G, Imamura M. Validation of intra-operative detection of paratracheal lymph node metastasis using real-time RT-PCR targeting esophageal squamous cell carcinoma. Jpn J Clin Oncol. 2003 Nov;33(11):549-55. (IF:0.967).

19、Shimada Y, Sato F, Maeda M, Watanabe G, Nagatani S, Kaganoi J, Hashimoto Y, Kan T, Li ZG(李志刚), Imamura M. Validity of intraoperative pathological diagnosis of paratracheal lymph node as a strategy for selection of patients for cervical lymph node dissection during esophagectomy. Dis Esophagus. 2003;16(3):246-51.(IF:0.797).

20、Ding Y, Shimada Y, Gorrin-Rivas MJ, Itami A, Li ZG(李志刚), Hong T, Maeda M, Komoto I, Kawabe A, Kaganoi J, Imamura M. Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma. Oncology. 2002; 63(4):378-84 (IF:2.114).

21、Shimada Y, Imamura M, Sato F, Maeda M, Kaganoi J, Hashimoto Y, Kan T, Nagatani S, Li ZG(李志刚). Indications for abdominal para-aortic lymph node dissection in patients with esophageal squamous cell carcinoma. Surgery. 2002 Jul;132(1):93-9.(IF:2.355).

22、Sato F, Shimada Y, Li ZG(李志刚), Kano M, Watanabe G, Maeda M, Kawabe A, Kaganoi J, Itami A, Nagatani S, Imamura M. Paratracheal lymph node metastasis is associated with cervical lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma. Ann Surg Oncol. 2002, Jan-Feb;9(1):65-70.(IF:4.035).

23、Hong T, Shimada Y, Uchida S, Itami A, Li ZG(李志刚), Ding Y, Kaganoi J, Komoto I, Sakurai T, Imamura M.Expression of angiogenic factors and apoptotic factors in leiomyosarcoma and leiomyoma. Int J Mol Med. 2001 Aug; 8(2):141-8.(IF:3.190).

24、sato F, Shimada Y, Li ZG(李志刚), Watanabe G, Maeda M, Imamura M. Lymph node micrometastasis and prognosis in patients with oesophageal squamous cell carcinoma. Br J Surg. 2001 Mar;88(3):426-32. (IF3.580).

25、Ding Y, Shimada Y, Kano M, Itami A, Kawabe A, Maeda M, Li ZG(李志刚), Hong T, Sato F, Kaganoi J, Imamura M. PTEN/MMAC1 expression in esophageal squamous cell carcinomas. Int J Oncol. 2000, Oct;17(4):695-9. (IF:2.295).

26、Kano M, Shimada Y, Kaganoi J, Sakurai T, Li ZG(李志刚), Sato F, Watanabe G, Imamura M. Detection of lymph node metastasis of oesophageal cancer by RT-nested PCR for SCC antigen gene mRNA, Br J Cancer. 2000 Jan;82(2):429-35. (IF:3.580).

27、Uchida S, Shimada Y, Watanabe G, Li ZG(李志刚), Hong T, Miyake M, Imamura M.Motility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma, Br J Cancer. 1999 Mar; 79 (7-8):1168-73. (IF:3.742).

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